Background paper: Evolution of the Existing Substances Risk Assessment Program under the Canadian Environmental Protection Act, 1999
Official title: Chemicals Management Plan Science Committee background paper: Evolution of the Existing Substances Risk Assessment Program under the Canadian Environmental Protection Act, 1999 and considerations looking forward Chemicals Management Plan (CMP) Science Committee meeting: February 17 to 18, 2021
John C
,
Achenbach
,
Cindy Leggiadro
,
Sandra A. Sperker
,
Cindy Woodland
,
Lee D. Ellis
Comparison of the Zebrafish Embryo Toxicity Assay and the General and Behavioral Embryo Toxicity Assay as New Approach Methods for Chemical Screening
Toxics 2020, 8(4), 126; https://doi.org/10.3390/toxics8040126 Absract: The movement away from mammalian testing of potential toxicants and new chemical entities has primarily led to cell line testing and protein-based assays. However, these assays may not yet be sufficient to properly characterize the toxic potential of a chemical. The zebrafish embryo model is widely recognized as a…
A.J.F. Reardon
,
A. Rowan-Carroll
,
S.S. Ferguson
,
K. Leingartner
,
R. Gagne
,
B. Kuo
,
A. Williams
,
L. Lorusso
,
J.A. Bourdon-Lacombe
,
R. Carrier
,
I. Moffat
,
C.L. Yauk
,
E. Atlas
High-throughput transcriptomics and benchmark concentration modeling for potency ranking of per- and polyfluoroalkyl substances (PFAS) in exposed human liver cell spheroids
Abstract: Per- and polyfluoroalkyl substances (PFAS) are some of the most prominent organic contaminants in human blood. Although the toxicological implications from human exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are well established, data on lesser-understood PFAS are limited. New approach methodologies (NAMs) that apply bioinformatic tools to high-throughput data are being increasingly considered…
Katie Paul Friedman
,
Matthew Gagne
,
Lit-Hsin Loo
,
Panagiotis Karamertzanis
,
Tatiana Netzeva
,
Tomasz Sobanski
,
Jill A Franzosa
,
Ann M Richard
,
Ryan R Lougee
,
Andrea Gissi
,
Jia-Ying Joey Lee
,
Michelle Angrish
,
Jean Lou Dorne
,
Stiven Foster
,
Kathleen Raffaele
,
Tina Bahadori
,
Maureen R Gwinn
,
Jason Lambert
,
Maurice Whelan
,
Mike Rasenberg
,
Tara Barton-Maclaren
,
Russell S Thomas
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
Toxicological Sciences, Volume 173, Issue 1, January 2020, Pages 202–225, https://doi.org/10.1093/toxsci/kfz201 Abstract: Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the potential to accelerate the pace of human health safety evaluation by informing screening-level assessments. The primary objective of this work was to compare PODs based on high-throughput predictions of…
Tara S
,
Barton-Maclaren
,
Maureen R. Gwinn
,
Russell S. Thomas
,
Robert J. Kavlock
,
Mike Rasenberg
Publication after third APCRA Workshop in Ottawa
Title: INSIGHT: New Approaches to Chemical Assessment- a Progress Report Bloomberg Law, Environment & Energy 2019
Robert J. Kavlock
,
Tina Bahadori
,
Tara S. Barton-Maclaren
,
Maureen R. Gwinn
,
Mike Rasenberg
,
Russell S. Thomas
Publication after second APCRA Workshop in Helsinki
Title: Accelerating the Pace of Chemical Risk Assessment Chemical Research in Toxicology 31 (5), 2018, Pages 287-290
Robert J.Kavlock
Publication after first APCRA Workshop in Washington DC
Title: Practitioner Insights: Bringing New Methods for Chemical Safety into the Regulatory Toolbox; It is Time to Get Serious BNA Daily Environment Report 223 DEN B-1, Pages 1-3