February 17, 2021

Background paper: Evolution of the Existing Substances Risk Assessment Program under the Canadian Environmental Protection Act, 1999

Official title: Chemicals Management Plan Science Committee background paper: Evolution of the Existing Substances Risk Assessment Program under the Canadian Environmental Protection Act, 1999 and considerations looking forward

Chemicals Management Plan (CMP) Science Committee meeting: February 17 to 18, 2021

Link to Publication

Feb 28, 2025

Marc A Beal

Marc Audebert

Tara Barton-Maclaren

Hannah Battaion

Jeffrey C Bemis

Xuefei Cao

Connie Chen

Stephen D Dertinger

Roland Froetschl

Xiaoqing Guo

George Johnson

Giel Hendriks

Francesco Cubadda

Laure Khoury

Alexandra S Long

Stefan Pfuhler

Raja S Settivari

Shamika Wickramasuriya

Paul White

Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose

Environ Mol Mutagen. 2023 Feb;64(2):105-122. doi: 10.1002/em.22521. Epub 2022 Dec 22. Abstract: Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, and aneugenicity) have been limited to dichotomous hazard classification, while other toxicity endpoints are assessed through quantitative determination of points-of-departures (PODs) for setting exposure limits. The more…

Feb 28, 2025

Olimpia Vincentini

Anne-Louise Blier

Alessia Bogni

Morgane Brun

Serena Cecchetti

Francesca De Battistis

Sylvain Denis

Lucie Etienne-Mesmin

Francesca Ferraris

Francesco Sirio Fumagalli

Kevin Hogeveen

Francesca Iacoponi

Andrea Raggi

Lisa Siciliani

Deborah Stanco

Eveline Verleysen

Valerie Fessard

Jan Mast

Stephanie Blanquet-Diot

Susanne Bremer-Hoffmann

Francesco Cubadda

EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects

EFSA Journal, Published 20 September 2023; https://doi.org/10.2903/sp.efsa.2023.EN-8258 Abstract: Nanocellulose (NC) is an emerging material in the food sector with several prospective application areas. Three main types of NC exist, i.e. bacterial NC (BNC), nanofibrillated cellulose (NFC), and cellulose nanocrystals (CNC). The biological sources and processing conditions affect several physicochemical parameters of NC. In the present project,…

Feb 28, 2025

Daniel L Villeneuve

Michelle Le

Monique Hazemi

Adam Biales

David C Bencic

Kendra Bush

Robert Flick

John Martinson

Mackenzie Morshead

Kelvin Santana Rodriguez

Kelsey Vitense

Kevin Flynn

Pilot testing and optimization of a larval fathead minnow high throughput transcriptomics assay

Current Research in Toxicology; https://pubmed.ncbi.nlm.nih.gov/36619288/ Abstract: Concentrations at which global gene expression profiles in cells or animals exposed to a test substance start to differ significantly from those of controls have been proposed as an alternative point of departure for use in screening level hazard assessment. The present study describes pilot testing of a high throughput…

Dec 1, 2022

Kristin K. Isaacs

Peter Egeghy

Kathie L. Dionisio

Katherine A. Phillips

Angelika Zidek

Caroline Ring

Jon R. Sobus

Elin M. Ulrich

Barbara A. Wetmore

Antony J. Williams

John F. Wambaugh

The chemical landscape of high-throughput new approach methodologies for exposure

Journal of Exposure Science & Environmental Epidemiology; https://doi.org/10.1038/s41370-022-00496-9 Abstract: The rapid characterization of risk to humans and ecosystems from exogenous chemicals requires information on both hazard and exposure. The U.S. Environmental Protection Agency’s ToxCast program and the interagency Tox21 initiative have screened thousands of chemicals in various high-throughput (HT) assay systems for in vitro bioactivity. EPA’s…

Nov 4, 2021

Yadvinder Bhuller

Deborah Ramsingh

Marc Beal

Sunil Kulkarni

Matthew Gagne

Tara S Barton-Maclaren

Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals

Front. Toxicol., 04 November 2021 | https://doi.org/10.3389/ftox.2021.748406 Abstract: In 2012, the Council of Canadian Academies published the expert panel on integrated testing of pesticide’s report titled: Integrating emerging technologies into chemical safety assessment. This report was prepared for the Government of Canada in response to a request from the Minister of Health and on behalf…

Mar 27, 2021

Andrea Rowan-Carroll

Anthony Reardon

Karen Leingartner

Remi Gagné

Andrew Williams

Matthew J Meier

Byron Kuo

Julie Bourdon-Lacombe

Ivy Moffat

Richard Carrier

Andy Nong

Luigi Lorusso

Stephen S Ferguson

Ella Atlas

Carole Yauk

High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization

Toxicological Sciences, Volume 181, Issue 2, June 2021, Pages 199–214 Abstract: Per- and poly-fluoroalkyl substances (PFAS) are widely found in the environment because of their extensive use and persistence. Although several PFAS are well studied, most lack toxicity data to inform human health hazard and risk assessment. This study focused on 4 model PFAS: perfluorooctanoic…

Dec 21, 2020

John C

Achenbach

Cindy Leggiadro

Sandra A. Sperker

Cindy Woodland

Lee D. Ellis

Comparison of the Zebrafish Embryo Toxicity Assay and the General and Behavioral Embryo Toxicity Assay as New Approach Methods for Chemical Screening

Toxics 2020, 8(4), 126; https://doi.org/10.3390/toxics8040126 Absract: The movement away from mammalian testing of potential toxicants and new chemical entities has primarily led to cell line testing and protein-based assays. However, these assays may not yet be sufficient to properly characterize the toxic potential of a chemical. The zebrafish embryo model is widely recognized as a…

Oct 21, 2020

A.J.F. Reardon

A. Rowan-Carroll

S.S. Ferguson

K. Leingartner

R. Gagne

B. Kuo

A. Williams

L. Lorusso

J.A. Bourdon-Lacombe

R. Carrier

I. Moffat

C.L. Yauk

E. Atlas

High-throughput transcriptomics and benchmark concentration modeling for potency ranking of per- and polyfluoroalkyl substances (PFAS) in exposed human liver cell spheroids

Abstract: Per- and polyfluoroalkyl substances (PFAS) are some of the most prominent organic contaminants in human blood. Although the toxicological implications from human exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are well established, data on lesser-understood PFAS are limited. New approach methodologies (NAMs) that apply bioinformatic tools to high-throughput data are being increasingly considered…

Sep 18, 2019

Katie Paul Friedman

Matthew Gagne

Lit-Hsin Loo

Panagiotis Karamertzanis

Tatiana Netzeva

Tomasz Sobanski

Jill A Franzosa

Ann M Richard

Ryan R Lougee

Andrea Gissi

Jia-Ying Joey Lee

Michelle Angrish

Jean Lou Dorne

Stiven Foster

Kathleen Raffaele

Tina Bahadori

Maureen R Gwinn

Jason Lambert

Maurice Whelan

Mike Rasenberg

Tara Barton-Maclaren

Russell S Thomas

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

Toxicological Sciences, Volume 173, Issue 1, January 2020, Pages 202–225, https://doi.org/10.1093/toxsci/kfz201 Abstract: Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the potential to accelerate the pace of human health safety evaluation by informing screening-level assessments. The primary objective of this work was to compare PODs based on high-throughput predictions of…

Jan 10, 2019

Tara S

Barton-Maclaren

Maureen R. Gwinn

Russell S. Thomas

Robert J. Kavlock

Mike Rasenberg

Publication after third APCRA Workshop in Ottawa

Title: INSIGHT: New Approaches to Chemical Assessment- a Progress Report Bloomberg Law, Environment & Energy 2019